Almost 13% of breast cancers are due to a hereditary predisposition associated with high or moderate penetrance of genes. The 2 genes most responsible for breast cancer are the BRCA1 gene on chromosome 17 and the BRCA2 gene on chromosome 13.
Prophylactic mastectomy is the only method that can significantly reduce the risk of breast cancer. It is estimated that prophylactic mastectomy can reduce the risk of breast cancer by 90-100%.
Women with a BRCA1/2 mutation are less likely to get ovarian cancer. Ameta-analysis10 research on women with BRCA mutation showed that the risk of ovarian cancer is reduced by 80% after salpingo-oophorectomy.
Women with BRCA1/2 gene mutation should undergo the following diagnostic tests.