Prophylactic mastectomy is the only method that can significantly reduce the risk of breast cancer. It is estimated that prophylactic mastectomy can reduce the risk of breast cancer by 90-100% if the surgery is performed by a specialized breast surgeon with total removal of the mammary gland.
Surgical procedures that can be performed are skin sparing and nipple sparing mastectomy with immediate reconstruction in the same surgery. Mastectomy must precede salpingo-oophorectomy in order to avoid complications. A sentinel lymph node biopsy is not performed in prophylactic mastectomy.